美国癌症相关静脉血栓栓塞的流行病学
Barbara D Lam1, Justine Ryu2, Omid Jafari3
1Division of Hematology & Oncology, Fred Hutch Cancer Center, University of Washington, Seattle, Washington, USA.
American journal of hematology
|March 9, 2026
概括
癌症患者面临着静脉血栓栓塞 (VTE) 的显著风险,累计发病率在6个月后为2.7%,在12个月后为3.7%. 在癌症诊断的第一年内发生的VTE与死亡率的增加有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 癌症相关静脉血栓塞栓症 (VTE) 之前的研究缺乏多样化的患者群体.
- 电子健康记录 (EHR) 数据为大规模的流行病学研究提供了宝贵的资源.
研究的目的:
- 评估与癌症相关的VTE的发病率和风险因素在一个大型的,代表性的美国患者队列中.
- 检查癌症诊断后第一年内VTE发生与患者死亡率之间的关联.
主要方法:
- 利用了Cosmos协作数据集,包括来自美国 (2018-2023) 的Epic EHR数据.
- 包括新确诊的癌症患者,计算6个月和12个月的累计VTE发病率.
- 采用考克斯回归来确定风险因素并评估VTE对死亡率的影响.
主要成果:
- 确定了1,628,626名患有癌症的患者.
- 报告的6个月VTE累计发病率为2.7%,12个月发病率为3.7%.
- 关键的风险因素包括以前的VTE,癌症类型,晚期和化疗. 第一年内的VTE独立地与死亡率增加有关.
结论:
- 与癌症相关的VTE是一个重大的问题,其发生率很高.
- 在癌症患者中识别和管理VTE风险因素对于改善结果至关重要.
- 癌症患者的早期VTE发生预示着更差的预后和增加的死亡风险.
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