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Updated: Mar 10, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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氨:Treg强度的代谢检查点之一

Ali Valipour Motlagh1, Eyad Elkord2, Weiwei Dai3

  • 1Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Ren'ai Road, Suzhou, Jiangsu 215123, People's Republic of China; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool, Liverpool, UK.

Trends in cancer
|March 9, 2026
PubMed
概括

氨为调节性T细胞 (Tregs) 提供燃料,使它们能够将废物转化为免疫抑制. 这一过程驱动了瘤的免疫逃避和对免疫疗法的抵抗.

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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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