相关实验视频
Updated: Mar 10, 2026

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Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
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突破 新冠病毒相关传染病 2019年 接种疫苗后在移植接受者中取得突破
Roy O Mathew1, Jiajia Zhang2, Ziang Liu2
1Division of Medicine, Department of Medicine, Loma Linda VA Healthcare System, Loma Linda, California; Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California.
Transplantation proceedings
|March 9, 2026
概括
接受移植的人在接种疫苗后面临更高的COVID-19风险. 强剂量显著减少突破性感染和严重后果在这个脆弱的人群.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 接受移植 (KT) 的人极易感染严重的COVID-19.
- 在KT患者中疫苗疗效数据需要进一步调查.
- 了解突破性感染风险对于这个高风险群体至关重要.
研究的目的:
- 评估KT接受者突破性COVID-19感染的风险因素.
- 为了比较KT接受者和非KT个体之间的感染和不良结果.
- 评估疫苗接种和强剂对KT患者COVID-19结果的影响.
主要方法:
- 美国全州卫生登记处 (2019-2022) 的回顾性分析.
- 倾向性比分匹配,将1270名KT受益人与2540名非KT个人进行比较.
- 考克斯的比例危险模型和几率比率用于分析感染风险和结果.
主要成果:
- 与非KT个体相比,KT接受者患COVID-19突破性感染的风险高出2.61倍.
- 补充疫苗接种显著降低了突破性感染风险 (OR:0.19).
- 突破性感染的KT患者面临住院 (OR: 18) 和死亡 (OR: 10.2) 的几率明显更高.
结论:
- 移植接受者仍然面临突破性COVID-19的高风险.
- 接种mRNA疫苗和复发剂量可以保护人免受感染和严重的后果.
- 持续的警和疫苗接种策略对于KT接受者至关重要.
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