附带敏感性的临床流行:对多中心抗微生物监测数据的系统探索
Sebastian T Tandar1, Laura B Zwep1, Sjoukje H S Woudt2
1Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
The Lancet. Microbe
|March 9, 2026
概括
附带敏感性是一种抗生素耐药性的策略,在临床细菌菌株中是罕见的. 然而,病原体之间保留的附带敏感性相互作用为新的抗生素疗法提供了潜力.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 细菌的副作用包括由于对另一种抗生素的耐药性而对一种抗生素的敏感性发生变化.
- 抵押品的敏感性 (增加的易受性) 和抵押品的抗性 (降低的易受性) 是关键现象.
- 基于附带敏感性的疗法是打击抗菌素耐药性的有希望的策略.
研究的目的:
- 系统地评估临床细菌菌株中附带敏感性的发生和模式.
- 在多种病原体物种中识别保存的附带敏感性相互作用.
主要方法:
- 对大规模抗菌素耐药性监测数据 (超过500万次MIC测量) 的分析.
- 检查86种抗生素和30种病原体物种,以确定双向和三向副作用.
- 量化全物种趋势,并比较抗生素类别内和之间的附带敏感性流行率.
主要成果:
- 附带敏感性发生在只有3.0%的物种-抗生素对,而附带耐药性为42.0%.
- 在四种细菌物种中保留了六对附带敏感性,包括ESKAPEE病原体.
- 大多数附带敏感性涉及不同类别的抗生素,除了β-lactams的一些例外.
结论:
- 在临床相关的病原体中,附带敏感性相互作用保持不变.
- 识别了保留的附带敏感性对,可以为新型抗生素治疗的开发提供信息.
- 这项研究支持预防和逆转抗菌素耐药性的策略.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
8.2K
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
27.9K
相关概念视频
Antimicrobial Effectiveness
1.6K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.6K
Urine Studies II: Urine Culture and Sensitivity Test
1.7K
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
1.7K
Healthcare Associated Infections II: Preventive Measures
4.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.6K
