6PPD-能促进卵巢癌的进展:来自网络毒理学,机器学习和体外验证的见解
Nannan Wang1, Jingyu Zhu1, Ningjuan Wu1
1Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061 Shaanxi Province PR China.
概括
6PPD- (6PPD-Q),是一种轮胎化学物质,通过与关键蛋白相互作用,促进卵巢癌 (OC) 细胞的增殖. 这项研究确定了6PPD-Q作为OC的潜在环境风险因素,并建议新的干预目标.
科学领域:
- 环境毒理学环境毒理学
- 在瘤学瘤学.
- 网络药理学网络药理学
背景情况:
- 6PPD- (6PPD-Q) 是由轮胎磨损引起的有毒环境污染物,已知具有生殖毒性.
- 6PPD-Q在卵巢癌 (OC) 的发展和进展中的特定作用尚不清楚.
研究的目的:
- 研究6PPD-Q在卵巢癌中的潜在瘤机制.
- 确定关键的分子标和途径,通过6PPD-Q可以促进OC.
主要方法:
- 综合网络毒理学和转录基因分析以确定6PPD-Q目标.
- 使用机器学习和SHAP分析来优先考虑核心生物标志物 (DDR1,ABL1,PDE2A,FRK,F10).
- 进行分子对接和体外测试 (CCK-8,殖民地形成,qRT-PCR) 进行验证.
主要成果:
- 确定了6PPD-Q和OC之间的26个交叉目标,优先考虑五个核心生物标志物.
- 通过分子对接,证实了6PPD-Q与优先级蛋白质之间的高结合亲和力.
- 证明6PPD-Q暴露在体外显著增强了OC细胞的增殖.
结论:
- 在6PPD-Q暴露,特定的分子标和OC细胞增殖之间建立了直接联系.
- 描述了6PPD-Q作为可能导致卵巢癌的环境因素.
- 突出了针对6PPD-Q诱导的OC干预的潜在治疗目标.
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