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Updated: Mar 10, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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IGF2BP3-GP130-STAT3-WTAP循环促进了质母细胞瘤的恶性进展

Wanli Yu1, Lunshan Peng1, Shihao Cai1

  • 1Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China; Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang University, Nanchang, Jiangxi 330006, China; JXHC key Laboratory of Neurological Medicine, Nanchang University, Nanchang, Jiangxi 330006, China; Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi 330006, China.

Cellular signalling
|March 9, 2026
PubMed
概括

胰岛素样生长因子2mRNA结合蛋白3 (IGF2BP3) 通过稳定GP130mRNA,激活STAT3通路,并促进m6A修饰,驱动质母细胞瘤 (GBM). 这创造了一个积极的反循环,促进GBM瘤发生.

关键词:
在GBMGBMGBMGBMGBM在GP130中,我们使用的是GP130在 IGF2BP3BP3 中.JAK2/STAT3 3 的情况.在WTAP中,使用的是WTAP.

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