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经鼻腔腹腔脑干刺激可以逆转麻醉引起的无意识在绵羊

Jingyu Feng¹, Bin Liu¹, Zhijun Zhao²

¹Department of Neurosurgery, Peking University Third Hospital, Beijing, 100089, China.

Brain stimulation

|March 9, 2026

概括

脑干网状形成 (BRF) 的跨鼻电刺激在羊中部分逆转了麻醉引起的无意识. 这种最少的侵入性方法调节了皮质活动和甲状腺皮质连接,为未来的意识障碍提供了潜在的潜力.

科学领域:

神经科学是一个神经科学.
麻醉学麻醉学
神经外科神经外科

背景情况:

脑干网状形成 (BRF) 对于调节兴奋至关重要.
总麻醉通过抑制BRF活动来诱导无意识.
通过鼻腔的方法提供了对腹部大脑干的最小侵入性访问.

研究的目的:

评估BRF跨鼻电刺激在逆转麻醉引起的无意识时的有效性.

主要方法:

绵羊在腹腔大脑干附近经历了外周/骨电极的跨鼻植入.
在麻醉下,对腹部脑干和丘脑进行电刺激.
记录了局部场势,以分析皮质功率和thalamocortical连接性.

主要成果:

腹腔大脑干刺激在失去意识时改变了皮层功率.
对BRF的外周刺激诱导了类似于清醒的皮质信号和额叶变化.
这种刺激逆转了α-β功率前置化,并增强了脑皮层连接.

结论:

过鼻式BRF刺激提供了一种用于调节意识网络的新方法.
这种方法对逆转麻醉引起的无意识有希望.
它可能为长期意识障碍提供未来的治疗策略.

关键词:

麻醉是一种麻醉.脑干刺激脑干刺激电力生理学电力生理学功能连接性的功能连接性没有意识,无意识.

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