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Updated: Mar 10, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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Published on: December 3, 2020

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LeiCNS-PK3.2:一个基于生理学的药动力学模型框架,用于预测乙克洛维尔和甘西克洛维尔活性代谢物的细胞内度

Ming Sun1, Martijn L Manson1, Tingjie Guo1

  • 1Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|March 9, 2026
PubMed
概括

一个新的模型 (LeiCNS-PK3.2) 预测了脑细胞中的抗病毒药物度,表明大脑细胞内液体中的活性三酸盐代谢物与细胞外水平不同. 这有助于优化对中枢神经系统感染的抗病毒剂量.

关键词:
阿西克洛维尔 (acyclovir) 是一种药物.中枢神经系统感染.中枢神经系统 (CNS) 的药理动力学甘西克洛维尔 (Ganciclovir) 是一种药物.细胞内部的药理动力学核酸类型的类似物.基于生理学的药理动力学 (PBPK) 建模.

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