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Updated: Mar 10, 2026

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对于先进的细胞模型而言,持续进化的人形
D Shimojo1, S Qiu2, M Sasamata3
1Innovation Lab., Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan..
SLAS technology
|March 9, 2026
概括
使用Maholo LabDroid的自动细胞培养通过改进诱导多能干细胞 (iPSC) 模型来增强药物发现. 这种机器人平台可以进行长期培养和复杂的测试,以获得更可靠的临床前结果.
科学领域:
- 生物技术是生物技术.
- 干细胞研究 干细胞研究
- 药物发现 药物发现 药物发现
背景情况:
- 由于传统动物模型在预测人类结果方面的局限性,药物发现面临高失败率 (90%).
- 使用诱导多能干细胞 (iPSCs) 的体外人体模型显示出希望,但由于长时间的培养时间和实验变异性而受到阻碍.
- 自动化对于推进人类仿生研究和提高基于iPSC的研究可靠性至关重要.
研究的目的:
- 优化Maholo LabDroid自动化细胞培养系统,用于长期无差异的iPSC培养和复杂的基于细胞的测试.
- 解决实时细胞监控,细胞供应和3D模型处理方面的局限性,以提高iPSC的利用率.
- 为先进的细胞模型建立一个平台技术,以改善药物发现和细胞疗法开发.
主要方法:
- 优化Maholo LabDroid,一个人形机器人系统,用于可复制的长期iPSC培养.
- 整合了机器人手臂辅助成像系统,用于实时细胞观察.
- 整合了支持蓝牙的电子管管和扩展培养容器选项,用于灵活的液体处理和3D模型生成.
主要成果:
- 优化的Maholo LabDroid平台可以长期培养不分化的iPSC,并执行复杂的测试.
- 实时成像和灵活的液体处理解决了iPSC研究中的关键局限性.
- 成功地实现了生理功能性有机体的自动生成,提供了足够的高质量的细胞.
结论:
- 马霍罗 LabDroid 平台提供先进的细胞模型,增强药物发现研究.
- 这种自动化系统提高了基于iPSC的研究的可靠性和效率.
- 该平台具有推动细胞治疗产品开发的潜力.
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