聚乙烯微塑料暴露对脂肪组织功能障碍的体外影响
Maria Sofia Molonia1, Santi Trischitta1, Federica Lina Salamone2
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
概括
聚烯微塑料 (MPs) 没有影响成熟的脂肪细胞. 然而,在分化过程中,MPs导致脂肪细胞生长,氧化应激和炎症,突出了特定阶段的风险.
科学领域:
- 环境健康 环境健康
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物.
- 越来越多的证据将国会议员与人类健康问题联系起来.
- 脂肪组织在新陈代谢健康中起着至关重要的作用.
研究的目的:
- 研究聚烯 (PS) MPs对3T3-L1脂肪细胞的影响.
- 评估在分化过程中对成熟脂肪细胞和细胞的影响.
- 评估MPs对脂肪生成,ER压力,氧化平衡和炎症的影响.
主要方法:
- 使用一种小鼠3T3-L1脂肪细胞在体外模型.
- 暴露分化的脂肪细胞和分化的前脂肪细胞到5μm PS MPs.
- 分析了脂肪生成,ER压力,炎症和氧化压力的关键标志物.
主要成果:
- PS MPs没有显著改变成熟脂肪细胞标志物用于脂肪生成,ER压力或炎症.
- 在分化过程中的暴露促进了脂肪细胞缩和上调的脂肪生成标志物.
- 国会议员诱导了反应性氧物种,ER压力,亡和炎症信号.
结论:
- 脂肪组织对PS MPs的反应取决于阶段.
- 在分化过程中,MPs会扰乱氧化平衡,ER平衡和炎症信号.
- 研究结果强调需要对环境污染物对脂肪组织的影响进行特定阶段的评估.
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