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Updated: Mar 10, 2026

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结构优化的可光交联的素-PEG水凝,增强了复星的封装和功能稳定性

Nesma S Abdelaty¹, Mostafa Gouda², Amel Thanina Amrouche³

¹College of Biosystems Engineering and Food Science, Key Laboratory for Quality Evaluation and Health Benefit of Agro-Products of Ministry of Agriculture and Rural Affairs, Key Laboratory for Quality and Safety Risk Assessment of Agro-Products Storage and Preservation of Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, 310058, China; Department of Dairy Science, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh, 33516, Egypt.

International journal of biological macromolecules

|March 9, 2026

概括

这项研究引入了一种新的紫外线诱导的光交叉链接方法,用于基于素的凝,显著改善了复星的封装和受控释放. 这一创新增强了用于制药应用的抗氧化特性.

科学领域:

材料科学材料科学材料科学
生物材料工程生物材料工程
药物输送系统药物输送系统

背景情况:

传统的基于素的凝输送系统的负载效率低,功能性能差.
开发先进的材料对于稳定像白醇这样的敏感生物活性物质至关重要.

研究的目的:

开发一种新的紫外线诱导的光交联策略,用于素-聚乙烯糖醇凝.
为了增强复星的稳定,并使得可控的分娩.
提高基于素的输送系统的功能性能.

主要方法:

利用紫外线诱导的光学交联来制造多孔的素-聚乙烯甘醇凝.
使用FTIR和13C NMR进行结构特征.
优化的配方参数,包括素度.
评估了凝时间,储存模块,降解行为和药物封装效率.
使用DPPH和ABTS试验评估的抗氧化活性.

主要成果:

实现了高的交叉连接度 (93.32%) 与10%的素,快速凝 (18s) 和六倍增加的存储模量.
证明有效的复星封装 (96.31%) 和保留 (86%在储存期间).
与非交叉连接系统相比,显示出显著增强的抗氧化性能 (27.03%更高的DPPH清除,46.12%更高的ABTS反应).

结论:

通过UV光交叉连接进行结构工程的素基凝显著提高了封装效率和敏感生物活性物质的受控释放.
开发的系统为制药应用提供了增强的稳定性和抗氧化特性.
这种方法为先进的药物输送系统提供了一个有希望的战略.

关键词:

素的交叉链接素快速凝的方法水凝生物聚合物的生物聚合物.光聚合的光聚合方式.

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