在手术前进行为期两周的非常低卡路里饮食,以减少切除肝脏前的肥胖症 (RESOLVE):多中心随机对照可行性试验
Jade Chynoweth1, Lexy Sorrell1, Helen Neilens2
1Medical Statistics Research Group, University of Plymouth, Plymouth, UK.
概括
这项研究探讨了肝脏肥胖症患者的肝脏手术前的非常低热量饮食 (VLCD). 虽然没有证明临床益处,但需要进一步的试验来评估VLCD.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 肝脏手术是肝脏瘤和转移的主要治疗方法.
- 非常低热量饮食 (VLCD) 在减肥和胆囊手术前用于减少肝脏大小.
- 这项研究调查了VLCD在肝脏脂肪的肝脏手术患者的可行性.
研究的目的:
- 为了评估一个非常低热量饮食 (VLCD) 的可行性,在患者接受肝脏手术 (LS) 肝硬化 (HS).
主要方法:
- 这是一项随机对照可行性试验,共有29名参与者.
- 干预组:VLCD (800千卡,80克蛋白质) 在LS前2周.
- 控制组:照常进行治疗.
- 评估可行性和临床结果:手术时间,血液损失,易于手术,住院,再入院和死亡率.
主要成果:
- 没有观察到群体之间的显著差异.
- 手术后90天内没有发生死亡.
- 14名参与者中有11人开始VLCD;6人坚持至少10天.
结论:
- 可行性研究由于样本规模较小,没有显示出临床益处.
- 需要进行一项最终的试验,以确定手术前的VLCD是否可以在肝脏手术前减少肝脏肥胖症.
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