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香的开可以通过调节肠道微生物群,胆酸代谢和m6A修改来缓解MASH

Jiewen Shi¹, Chaoqun Zhao², Dingqi Zhang³

¹Department of pharmacy, The NATCM Third Grade Laboratory of Traditional Chinese Medicine Preparations, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai 201203, China; Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai 201203, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|March 9, 2026

概括

(XYXD) 通过重新平衡肠道微生物群,胆汁酸和表观遗传修饰来治疗与代谢功能障碍相关的脂肪肝炎 (MASH),影响酸代谢以获得治疗益处.

科学领域:

肝病学和胃肠病学肝病学和胃肠学
药理学和治疗学药理学和治疗学
微生物学和免疫学

背景情况:

代谢功能障碍相关的脂肪肝炎 (MASH) 是一个日益严重的全球健康问题,治疗选择有限.
(XYXD) 是一种传统的中国草药配方,在临床上用于MASH,但其分子机制尚未完全理解.

研究的目的:

在MASH中阐明XYXD的治疗机制.
调查XYXD对肠道微生物群,胆酸 (BA) 代谢,N6 - 甲基氨酸 (m6A) 修饰和酸 (AA) 代谢的影响.

主要方法:

建立了一个MASH模型,使用甲氨酸-胆缺乏 (MCD) 饮食.
通过16S rRNA测序和代谢学 (BA,AA) 分析肠道微生物群,使用LC-MS/MS.
评估与脂质平衡,炎症和m6A修改相关的基因和蛋白质表达.
使用脱氧胆酸 (DCA) 和XYXD处理的巨体进行了体外研究.

主要成果:

通过调节炎症和脂质代谢,XYXD在MASH中证明了治疗效果.
XYXD扭转了MCD饮食诱导的微生物群失衡,并通过FXR-SHP通路维持了BA稳态,减少了Clostridium和DCA.
发现DCA可上调甲基转移酶类13/14mRNA,增强m⁶A修饰并影响AA代谢.

结论:

XYXD通过多方面的机制缓解MASH,包括通过FXR-SHP轴调节肠道微生物群和BA稳态.
XYXD调节m6A的转录修饰,影响AA代谢,并建立微生物群和代谢途径之间的交叉通话.
这些综合行动突显了XYXD在MASH.系统干预方面的潜力.

关键词:

阿拉基酸是一种胆酸是什么意思胆酸是什么意思代谢功能障碍相关的脂肪肝炎 N(6) - - 甲基氨酸.西亚苏的蒸.

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