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CD28通路阻断导致移植耐受性:扩大免疫调节的领域

Mohammad Afzal Khan¹

¹Department of Surgery, University of Maryland, Health Sciences Research Facility III, 670 W Baltimore St, Baltimore, MD 21201, USA.

Current research in translational medicine

|March 9, 2026

概括

向CD28通路提供了一种有希望的策略,通过调节T细胞激活和调节T细胞功能来增强移植移植的接受能力. 未来的疗法旨在通过先进的药物和生物标志物来个性化诱导耐受性.

科学领域:

免疫学免疫学免疫学
移植免疫学移植免疫学
药物发现药物发现

背景情况:

移植需要平衡自我耐受性和免疫力,而非免疫激活是一个主要的挑战.
CD28/CD80-86通路对于T细胞激活和调节T细胞 (Treg) 功能至关重要,使其成为促进移植接受的关键目标.

研究的目的:

审查用于移植的CD28导向辅助刺激疗法的机制性见解和临床进展.
探索新兴的战略,以实现持久的,特定器官的移植接受.

主要方法:

在移植中对CD28共刺激的机械学数据的综合.
审查CD28向治疗的临床结果,如belatacept.
分析下一代代理商和个性化的方法.

主要成果:

贝拉塔cept显示了长期改善的功能,但强调了由于冗余的辅助刺激途径,需要联合治疗.
下一代CD28抗剂和工程生物制剂提供了扩展的治疗选择.
生物标志物导向剂量和基于细胞的调节疗法承诺个性化耐受性诱导.

结论:

调节CD28通路对于在移植中实现持久免疫耐受性至关重要.
未来的战略包括将新的CD28向药物与精确生物标志物和调节性细胞疗法结合起来,以优化移植接受.

关键词:

通过CD28路径.造价刺激的封锁造价刺激的封锁监管性T细胞 (Tregs) 的使用移植耐受性移植耐受性

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