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对于反应性物种的刺激反应性化物,化物和硫化物捐赠者化学生物学化学生物学

Ravi Tripathi¹, Rynne A Hankins¹, Jun Yi¹

¹Department of Chemistry, Wake Forest University, Wake Downtown Campus, Winston-Salem, North Carolina 27101, United States.

Journal of the American Chemical Society

|March 9, 2026

概括

研究人员开发了一种新平台,用于产生像素和硫素等反应性物种 (RSeS),这些物种对细胞氧化还原调节至关重要. 这一突破使其生物作用和治疗潜力的受控研究成为可能.

科学领域:

生物有机化学生物有机化学
化学生物学化学生物学
转毒生物学转毒生物学

背景情况:

反应性物种 (RSeS),包括化,硫化和硫化,是化 (H2Se) 信号和氧化还原调节中的拟议生物中间体.
对RSeS的不稳定性和缺乏合适的前体,阻碍了在生理条件下的直接实验研究.

研究的目的:

开发和描述一种新的刺激反应性捐赠平台,用于在生物环境中控制生成RSeS.
研究RSeS的反应性,氧化还原信号和治疗潜力.

主要方法:

合成和分离一个模块化的1,6消除供体平台用于RSeS生成.
通过酶激活控制RSeS的释放,可调节的稳定性和动力学.
在醇丰富的条件下进行计算分析和研究,以阐明RSeS形成途径.
对RSeS捐赠者的抗氧化和抗增殖活动的生物评估.

主要成果:

报告了对刺激响应的RSeS捐赠平台的首次合成和表征.
通过修改实现了分立的RSeS物种 (perselenides, thioselenides, selenosulfides) 的可调节释放.
二和二的捐赠者在富含二醇的条件下被证明会汇聚到共同的RSeS.
RSeS捐赠者表现出强大的抗氧化活性 (高达硫类比的100倍) 和在癌细胞中显著的抗增殖作用.

结论:

已经建立了一个新的,可调节的RSeS捐赠者类别,为控制RSeS生成提供了第一个通用平台.
这个平台可以系统地研究RSeS反应性,氧化还原信号以及体外和体内治疗应用.
这些发现凸显了反应性物种对生物的影响和治疗前景的重大意义.

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