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随时间变化的大脑功能重构模式与多发性硬化症中疲劳相关

Stefanie Hechenberger^1,2,3, Tommy A A Broeders⁴, Marloes D A Bet⁴

¹Department of Neurology, Research Unit for Neuroplasticity and Repair, Medical University of Graz, Graz, Austria.

Human brain mapping

|March 9, 2026

概括

多发性硬化症 (pwMS) 患者的疲劳与不稳定的大脑网络重新配置有关. 增加大脑区域的分散,特别是在边缘网络中,可能会导致MS相关的疲劳.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
神经学神经学

背景情况:

疲劳影响了多发性硬化症 (pwMS) 患者的很大一部分,严重影响了日常生活.
与MS相关的疲劳的潜在神经生物学机制尚不清楚.
异常的时间变化的大脑网络重新配置可能在MS疲劳中起作用.

研究的目的:

为了研究时间变化的脑网络重新配置和pwMS中的疲劳之间的关联.
探索网络重新配置的特定模式是否与运动和认知疲劳相关.

主要方法:

横截面研究涉及155个pwMS和48个健康对照 (HC).
休息状态功能性MRI被用来评估时间变化的功能连接.
网络重新配置的措施包括放荡性,灵活性,凝聚力和脱节性.
使用运动和认知功能的疲劳量表来评估疲劳.

主要成果:

在pwMS中,较高的总和运动疲劳与增加的全球大脑网络乱交和不连接性相关.
运动疲劳也与更大的网络灵活性有关.
边缘网络变性增加与pwMS中较高的总体和运动疲劳有关.
在控制临床因素和脑损伤后,这些关联仍然很重要.

结论:

在pwMS中疲劳水平升高与更不稳定和分散的大脑网络重新配置有关.
边缘网络的不稳定性可能特别重要,可能反映了奖励处理功能障碍.
这些发现表明,大脑网络动态的改变有助于在多发性硬化症中体验疲劳.

关键词:

大脑网络大脑网络疲劳疲劳疲劳疲劳疲劳疲劳多发性硬化症多发性硬化症时间变化的重新配置.

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