临床医生对药物基因组学临床服务的满意度在一个多州卫生系统
Kristen Jacobsen1, Natasha J Petry1,2, Max Weaver1
1Sanford Imagenetics, Sanford Health, Sioux Falls, South Dakota, USA.
Clinical and translational science
|March 9, 2026
概括
临床医生对药物基因组学 (PGx) 服务的满意度很高,特别是在药剂师笔记和决策支持方面. 虽然PGx对患者的结果产生了积极的影响,但向患者解释结果仍然是一个挑战.
科学领域:
- 临床药理学 临床药理学
- 遗传学 遗传学 是一个
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物基因组学 (PGx) 使用遗传信息优化药物管理.
- 实施PGx的障碍包括临床医生的知识有限,时间和财务限制.
- 关于临床医生对现有PGx临床服务的满意度的数据有限.
研究的目的:
- 评估临床医生对单一卫生系统内的PGx服务的满意度.
- 确定PGx服务的特定领域,有助于临床医生满意度.
- 了解临床医生报告的与PGx实施有关的影响和障碍.
主要方法:
- 一项内部开发的调查分发给了在过去3年内使用PGx服务的645名临床医生.
- 在2025年6月,从共36名参与的临床医生收集了调查答案.
- 对各种临床服务领域的满意度进行了评估,包括订购,EHR集成和结果返回.
主要成果:
- 临床医生对大多数PGx临床服务领域表示高度满意,特别是药剂师笔记和临床决策支持.
- 大多数受访者表示,PGx结果对患者的结果产生了积极的影响.
- 近一半的临床医生在向患者解释PGx结果时遇到了障碍,这表明PGx诊所的作用.
结论:
- 临床医生通常对目前的PGx临床服务感到满意,强调药剂师支持和决策支持工具的价值.
- 尽管满意度很高,但在将PGx结果传达给患者方面仍然存在挑战.
- PGx诊所可能提供一种解决方案,以减轻患者结果解释的障碍,改善整体PGx实用性.
相关概念视频
Pharmacogenetics and Pharmacogenomics: Overview
104
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
104
Pharmacogenomics: Identification of New Drug Targets
57
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
57
Pharmacogenetics of Drug Metabolism: Overview
77
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
77
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
80
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
80
Principles of Pharmacogenetics: Types of Genetic Variants
68
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
68
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
81
Cytochrome P450 (CYP450) enzymes are a superfamily of heme-containing monooxygenases that play a pivotal role in Phase I drug metabolism by catalyzing oxidation and reduction reactions.These enzymes transform lipophilic xenobiotics into more hydrophilic metabolites, facilitating subsequent Phase II conjugation and eventual excretion. The CYP450 family is classified into families (e.g., CYP1–CYP3) and subfamilies (e.g., CYP2A, CYP2C), based on amino acid sequence homology.CYP450...
81


