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Updated: Mar 10, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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基氨基酸通过预先组织 γ-转变来增加宏循环的被动透性和口服生物可用性

Nishant Raj1, Joyati Das1, Raju S Rajmani1

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.

Journal of medicinal chemistry
|March 9, 2026
PubMed
概括

加入α-aminoisobutyric酸 (Aib) 通过稳定构造来增强宏环 (MCP) 透性. 这一策略提高了口服生物可用性,为药物开发提供了一个新的设计元素.

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