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血液培养量与污染物和病原体恢复的定量关联

Amos Cahan¹, Nadav Sorek², Tal Brosh-Nissimov^1,3

¹Infectious Diseases and Infection Control Unit, Samson Assuta Ashdod University Hospital, Ashdod 7747629, Israel.

Infectious medicine

|March 9, 2026

概括

血液培养体积的增加与更高的污染率相关,特别是在常见的食肉动物中. 这表明在较大的样本中改善了生长条件或潜在的细菌病.

科学领域:

临床微生物学临床微生物学
传染性疾病传染性疾病
诊断实验室科学诊断实验室科学

背景情况:

血液培养物污染是一个经常出现的问题,具有重大临床后果.
血液培养量对污染率的影响需要进一步调查.
了解这种关系对于优化诊断准确度至关重要.

研究的目的:

评估血液培养体积与污染率之间的关联.
描述污染物物种在低体积和高体积样本中的相对丰度.
为微生物学收集血液的最佳实践提供信息.

主要方法:

从2017年8月到2023年8月对146307个血液培养瓶进行了回顾性分析.
包括0-10毫升液体体积的样本;排除临床数据.
使用后勤回归进行统计分析,以评估体积-培养的阳性相关性.

主要成果:

对病原体和污染物 (分别为每毫升1.033和1.030) 的血液体积和培养阳性之间观察到正相关性.
较大的体积样本 (10毫升与2毫升相比) 显示过多污染率为每1000种培养中的10种.
在大量样本中,Cutibacterium物种更普遍;其他污染物没有显著差异.

结论:

增加的血液体积与更高的阳性血液培养的可能性有关,包括污染物.
这一发现可能表明污染物在更大量的增长,或者在某些情况下,反映了真正的细菌.
优化血液体积对于准确的血液培养诊断至关重要.

关键词:

细菌病是什么意思细菌病是什么意思血液培养血液培养是什么?交叉体是一个共体体.污染污染污染污染样品血液体积量样品血液体积

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