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Updated: Mar 10, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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Published on: May 14, 2021

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乌比奎丁E3结合酶KLHL6使耗尽的T细胞重新起作用

Zhuoyao Chen1, Alex N Bullock1, Benedikt M Kessler1,2

  • 1Centre for Medicines Discovery, Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ UK.

Immunity & inflammation
|March 9, 2026
PubMed
概括

凯尔奇类蛋白质KLHL6在慢性抗原暴露期间防止T细胞耗尽,这对于有效的癌症免疫疗法至关重要. 恢复KLHL6功能可以通过保持T细胞功能来增强抗瘤免疫力.

关键词:
在CD8+淋巴细胞中.E3 结合酶的使用凯尔奇类蛋白质是一种类似凯尔奇的蛋白质.T细胞耗尽的情况.乌比奎丁是一种存在的药物.

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