聚乙烯四甲酸微塑料通过巨细胞介导的cGAS-STING铁灭菌破坏勃起功能
Siyu Liu1, Wenhao Wang2, Yijun Zhang1
1Department of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
iScience
|March 9, 2026
概括
聚乙烯四甲酸微塑料 (PET-MPs) 通过引发炎症和细胞死亡,使勃起功能障碍 (ED) 恶化. 向巨驱动的途径可能为微塑料诱导的ED提供新的治疗方法.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 微塑料污染是一个日益严重的全球问题.
- 微塑料对男性生殖健康,特别是勃起功能障碍 (ED) 的影响尚不清楚.
研究的目的:
- 调查慢性聚乙烯二烯甲微塑料 (PET-MP) 暴露对男性生殖健康的影响.
- 阐明将PET-MP暴露与ED相关的潜在机制.
主要方法:
- 在患有ED和没有ED的患者的人体洞腔体 (CC) 组织中评估了PET-MP水平.
- 在慢性PET-MP暴露研究中使用了一种老鼠模型.
- 采用细胞测试来研究细胞机制,包括巨细胞反应和线粒体功能.
主要成果:
- 在ED患者的CC组织中观察到更高的PET-MP负担.
- 慢性PET-MP暴露对大鼠的剂量依赖性勃起功能受损,纤维化增加和光滑肌肉减少.
- PET-MPs诱导了巨细胞的线粒体功能障碍,ROS生成,mtDNA释放,cGAS-STING激活和铁,导致炎症和内皮细胞转移到介质酶.
结论:
- 一个cGAS-STING-ferroptosis信号轴将环境PET-MP暴露与ED联系起来.
- 天生的免疫反应和铁亡途径与微塑料诱导的男性生殖功能障碍有关.
- 针对这些途径为微塑料暴露引起的ED提供了潜在的治疗策略.
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