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性纳米颗粒激活的口水可以对抗癌前的口腔粘膜炎症
Meijun Du1,2, Kunyu Wang1,2, Quanxin Ning1,3
1State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Regenerative biomaterials
|March 9, 2026
概括
唾液无细胞DNA (cfDNA) 触发与口腔癌相关的炎症. 一种使用子纳米颗粒的新口水可以去除cfDNA,减少炎症和癌前病变的发展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
背景情况:
- 慢性口腔粘膜炎是口腔状细胞癌 (OSCC) 的前体.
- 免疫平衡调节是拦截炎症驱动的OSCC发展的关键.
- 在前癌性口腔炎中,关键的炎症危险信号需要识别以进行有针对性的干预.
研究的目的:
- 在癌前的口腔粘膜炎症中识别炎症危险信号.
- 制定适用于本地的免疫调节策略,以预防这种炎症.
- 研究唾液无细胞DNA (cfDNA) 和其相关途径在OSCC中的作用.
主要方法:
- 量化唾液cfDNA水平和评估与OSCC相关的cfDNA诱导的TLR9激活.
- 开发了化纳米粒子启用口水,以去除负电荷cfDNA.
- 评估了纳米颗粒和聚合物的疗效in vitro使用OSCC患者血和in vivo在癌前小鼠模型.
主要成果:
- 升高的唾液cfDNA水平和TLR9激活与OSCC的发展和进展相关.
- 阴离子纳米粒子和聚合物抑制了体外的促炎反应,并抑制了OSCC患者的血诱导的瘤细胞迁移和干细胞.
- 纳米颗粒支持的口水通过抑制TLR9激活,在癌前小鼠模型中减少了口腔粘膜炎症.
结论:
- 唾液cfDNA是OSCC进展的一个关键因素.
- 子纳米粒子启用口水有效准cfDNA,以减轻癌前口腔炎症.
- 这种新型的口水为预防和治疗与OSCC相关的癌前病变提供了一个有希望的策略.
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