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塑化剂类型对LM-pectin水凝的结构和药物释放特性的影响

Banu Kocaağa¹, Fatma Seniha Güner^1,2

¹Department of Chemical Engineering, Faculty of Chemical and Metallurgical Engineering, İstanbul Technical University, İstanbul, Turkiye.

Turkish journal of chemistry

|March 9, 2026

概括

不同的增塑剂显著改变低甲基丁水凝药物释放. 麻油 (CO) 增强释放,而聚乙烯糖醇 (PEG) 和聚乙烯 (PVP) 则可用于药物释放系统的长时间,可控的输送.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
制药科学制药科学

背景情况:

低甲素pectin (LM-pectin) 水凝对药物输送有希望.
从水凝中控制药物释放需要了解塑化剂对矩阵性质的影响.

研究的目的:

为了研究不同可塑剂 (麻油,聚乙烯,聚乙烯糖醇) 如何影响LM-pectin水凝结构和神林药物释放.
为了将增塑剂类型和分子量与水凝特性和药物释放动力学相关联.

主要方法:

用各种可塑剂制备LM-pectin水凝:麻油 (CO),聚乙烯 (PVP) 和不同分子量 (MWs) 的聚乙烯糖醇 (PEG).
使用里埃变换红外光谱学 (FTIR) 和差分扫描热度计 (DSC) 进行了表征.
在生理学上相关的条件下进行了体外药物释放研究,随后进行了动力学分析.

主要成果:

麻油 (CO) 干扰了pectin包装,为更高的累积药物释放创造了途径.
聚烯利 (PVP) 水凝显示出增加的结晶性和更慢的药物释放.
聚乙烯甘醇 (PEG) 配方表现出分子重量依赖的释放动力学,更高的MWs导致更慢,扩散控制的释放.
对于PEG400和PEG1000,观察到非Fickian传输,而PEG1500则显示出额外的扩散有限的特征.

结论:

选择可塑剂对于为特定药物输送需求量身定制LM-pectin水凝性能至关重要.
碳化合物适用于高累积释放,而PEG1500和PVP适用于长期,扩散控制的药物管理.
这些LM-pectin配方具有控制皮肤和粘膜药物递送系统的潜力.

关键词:

对于LM-pectin来说,这是一个很好的方法.有控制释放的释放.药物释放动力学药物释放动力学这是一种水凝.塑化剂塑化剂塑化剂

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