在胃肠内镜中用于镇静的西普罗-利多卡因组合:系统性审查和元分析协议
1Department of Anaesthesiology, Unit of Emergency Anaesthesia, Burn Intensive Care and Poison Control Centre, AORN Antonio Cardarelli Naples Italy.
将静脉注射利多卡因添加到胃肠内镜中使用的西普罗镇静剂中,可能会减少西普罗的剂量. 本系统审查评估了这种组合的疗效和安全性,可能改善镇静策略.
科学领域:
- 麻醉学 麻醉学
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 西普罗提供与普罗波相似的镇静作用,具有更好的血液动力学稳定性和更少的不良事件.
- 静脉注射的利多卡因是用于普罗波福镇静的常见辅助剂,减少了催眠需求并有助于恢复.
- 在胃肠道内镜中,西普罗福和利多卡因的联合使用缺乏系统的评估.
研究的目的:
- 系统地审查和元分析随机对照试验,评估静脉注射利多卡因作为基于西普罗的镇静剂的辅助剂.
- 为了确定西普罗-利多卡因组合是否与胃肠道内镜中单独使用西普罗相比,提高了程序的有效性和安全性.
- 为未来的多模式镇静策略和临床实践提供信息.
主要方法:
- 遵守PRISMA指导方针和在PROSPERO (CRD420251166027) 进行潜在注册.
- 包括随机对照试验,比较肠胃内镜检查的成年患者的西普罗-利多卡因与单独的西普罗.
- 主要结局:总累积西普罗福尔剂量 (mg.患者-1). 使用固定或随机效应模型进行数据综合,使用RoB 2.0进行偏差风险评估,使用GRADE对证据的确定性进行分级.
主要成果:
- 该部分将在系统性审查和元分析完成后填写.
- 关于西普罗剂量,程序疗效和安全结果的预期发现.
结论:
- 这次审查将是关于利多卡因作为胃肠道内镜治疗中西普罗镇静剂的辅助剂的第一个全面综合证据.
- 结果将提供关于这种组合的有效性和安全性的见解.
- 结果旨在指导未来的多模式镇静策略和临床实践.
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