怀孕期间甲状腺功能障碍与新生儿神经发育结果之间的关联
1Obstetrics Department, Shanxi Province Fenyang Hospital, Fenyang, Shanxi, China.
Frontiers in pediatrics
|March 9, 2026
概括
怀孕期间甲状腺功能障碍会对新生儿的神经发育产生负面影响,根据具体的甲状腺状况有不同的影响. 在受影响的新生儿中,较低的FT4/FT3和较高的TSH水平与较差的神经发育分数相关.
科学领域:
- 内分泌学 在内分泌学.
- 新生儿神经病学 新生儿神经病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 甲状腺激素对于胎儿大脑发育至关重要.
- 怀孕期间母亲的甲状腺功能障碍可能会影响后代的神经发育.
- 了解不同类型的甲状腺功能障碍的具体影响至关重要.
研究的目的:
- 研究母亲甲状腺功能障碍与新生儿神经发育结果之间的关联.
- 为了比较甲状腺功能障碍和没有甲状腺功能障碍的母亲的新生儿之间的神经发育评估.
- 分析特定类型的甲状腺功能障碍对新生儿神经行为评估的影响.
主要方法:
- 前性研究比较甲状腺功能障碍组 (TDG,n=92) 与正常对照组 (NCG,n=150).
- 新生儿行为神经评估 (NBNA) 在新生儿身上进行.
- 血清甲状腺激素 (TSH,FT4,FT3) 在新生儿中测量;母亲的甲状腺状况分类.
主要成果:
- 与NCG相比,TDG中的新生儿的NBNA总得分,FT4和FT3水平明显较低,TSH水平较高 (P < 0.001).
- 在不同类型的母体甲状腺功能障碍中,神经发育结果有显著差异 (P < 0.05).
- 在TDG中,NBNA总得分与TSH (r=-0.242,P<0.05) 有负相关,FT4 (r=0.464,P<0.05) 和FT3 (r=0.383,P<0.05) 有正相关.
结论:
- 怀孕期间母亲甲状腺功能障碍显著影响新生儿神经发育结果.
- 甲状腺异常的特定类型会影响神经发育效应的严重程度.
- 这些发现强调了监测和管理孕妇甲状腺健康的重要性.
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