由于艾滋病毒患者的cystoisospora belli的反复腹:一个病例报告
Ana Victoria Gaxiola Ortiz1, Jorge Arturo Valdivieso-Jimenez2, Jairo R Villanueva-Toledo3,4
1Infectious Diseases, Hospital Regional de Alta Especialidad de la Península de Yucatán IMSS Bienestar, Merida, MEX.
Cureus
|March 9, 2026
概括
尽管接受治疗,但在一些艾滋病毒感染者中,cystoisospora belli感染仍然存在. 当标准方法失败时,先进的PCR测试对于诊断至关重要,强调需要持续的管理策略.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 传染性疾病 传染性疾病
- 艾滋病毒 医学 艾滋病毒 医学
背景情况:
- 囊虫 (Cystoisospora belli) 是一种机会性原生虫病原体,会影响免疫力低下的个体,尤其是感染艾滋病毒的人.
- 抗逆转录病毒疗法 (ART) 和trimethoprim/sulfamethoxazole (TMP-SMX) 预防已减少发病率,但感染仍然存在,特别是在免疫复原期间.
- 囊胞仍然是拉丁美洲慢性腹,脱水和吸收不良的重要原因,增加了发病率和死亡率.
研究的目的:
- 报告艾滋病毒阳性个体的复发性Cystoisospora belli感染病例,该个体的CD4数量很高,对ART的坚持良好.
- 突出诊断挑战和分子方法在识别C. belli.的实用性.
- 讨论治疗结果和二次预防的必要性.
主要方法:
- 一个27岁的CisGender男人的病例报告生活与艾滋病毒.
- 试图通过标准的寄生虫学便检查进行初步诊断.
- 使用胃肠多重聚合酶连锁反应 (PCR) 面板进行确认诊断.
主要成果:
- 标准便检测结果对C. belli.呈阴性.
- 多重PCR小组成功识别了C. belli.
- 患者经历了多次TMP-SMX疗程,只出现了部分改善,需要持续的二次预防.
结论:
- 即使在看似受控的免疫状况 (CD4>200细胞/毫米3) 和良好的ART坚持的HIV患者中,Cystoisospora belli也可能导致复发性感染.
- 多重PCR面板提供了一个有价值的诊断工具,当传统方法是不确定的.
- 有效管理C. belli可能需要长期治疗和二次预防,即使在接受治疗的HIV患者中也是如此.
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