塞法列辛诱导的自身免疫血液溶解性贫血:一个病例报告
Jesse Albano1,2, Allison Mogensen2, Cara Christopher3,4
1Department of Pharmacy, Maimonides Medical Center, Brooklyn, USA.
Cureus
|March 9, 2026
概括
药物诱导的免疫血液溶解性贫血 (DIIHA) 是罕见的,但塞法莱克辛可以引起它. 这一案例凸显了早期识别DIIHA症状的重要性,以便及时诊断和治疗.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自身免疫血液溶解性贫血 (AIHA) 包含像药物诱导免疫血液溶解性贫血 (DIIHA) 这样的血清学亚型.
- 诊断通常依赖于药物暴露和症状发作之间的时间联系.
- 塞法莱克辛很少与DIIHA相关,之前只有四例病例报告.
研究的目的:
- 在暴露于塞法列克辛后报告AIHA病例.
- 为了强调诊断挑战和CEPHALEXIN诱导的DIIHA的临床表现.
- 为了提高人们对DIIHA的认识,DIIHA是塞法莱克辛的次要产物.
主要方法:
- 一个85岁的女性呈现AIHA症状的病例报告.
- 临床评估包括血红蛋白水平和直接抗体检测.
- 在停止服用塞法莱克辛后,对血清学标记和治疗反应的监测.
主要成果:
- 患者在开始服用塞法莱克辛三天后出现严重的贫血 (血红蛋白4.7g/dL) 和阳性直接抗球蛋白测试 (IgG和C3).
- 在停止服用塞法莱克辛后,通过输血,IVIG和普雷迪尼松缓解症状.
- 之前使用黄素并没有引起免疫反应.
结论:
- 快速发作和解消强烈表明塞法列辛诱导的DIIHA.
- 塞法莱克辛可以引起严重的DIIHA,需要及时识别和管理.
- 早期识别和停止违规药物对DIIHA治疗至关重要.
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