超越针头:重新想象胰岛素输送和吸入胰岛素的演变
Prasanna Kumar K M1, Vijay Viswanathan2,3, Banshi Saboo4
1Department of Endocrinology, Center for Diabetes and Endocrine Care (CDEC), Bengaluru, IND.
Cureus
|March 9, 2026
概括
非侵入性胰岛素输送,特别是像Technosphere®胰岛素 (Afrezza®) 这样的吸入性胰岛素,可以改善患者对糖尿病管理的遵从性. 本综述探讨了肺胰岛素的发展和益处.
科学领域:
- 内分泌学和糖尿病管理
- 药理动力学和药物输送系统
- 呼吸系统医学 呼吸系统医学
背景情况:
- 胰岛素治疗对于糖尿病至关重要,由于侵袭性施用而面临挑战,影响患者的遵守.
- 为了克服这些障碍,正在积极研究非侵入性胰岛素输送方法.
- 肺部路线已成为一个有前途的途径,导致了吸入胰岛素的发展.
研究的目的:
- 为了审查胰岛素的肺部 route.
- 详细介绍吸入胰岛素的发展史.
- 专注于Technosphere®胰岛素 (Afrezza®) 作为唯一批准的吸入性胰岛素产品.
主要方法:
- 对非侵入性胰岛素输送研究的文献综述.
- 对吸入胰岛素的药理动力学概况和临床结果的分析.
- 检查监管部门的批准和Technosphere®胰岛素的市场可用性.
主要成果:
- 肺部途径已经成功地产生了唯一批准的非侵入性胰岛素选择:吸入胰岛素.
- 十多年来,Technosphere®胰岛素 (Afrezza®) 已用于成人糖尿病治疗.
- 胰岛素的创新旨在提高疗效,安全性和患者的遵从性.
结论:
- 吸入胰岛素,特别是Technosphere®胰岛素,通过解决传统胰岛素注射的局限性,代表了糖尿病护理的重大进步.
- 肺部路线提供了一种可行的非侵入性替代方案,改善了患者的坚持和潜在的血糖控制.
- 对非侵入性胰岛素输送的持续研究对于优化糖尿病管理策略至关重要.
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