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远程缺血调节可以改善COVID-19患者的神经精神症状:一项随机临床试验

Yaxuan Wu^1,2, Mengfan Li², Haiying Li^2,3

¹Department of Neurology, Xichang People's Hospital, Xichang, Sichuan, China.

Frontiers in psychiatry

|March 9, 2026

概括

远程缺血调节 (RIC) 改善了认知功能,并减少了COVID-19幸存者的失眠,焦虑和抑郁症. 这种非侵入性疗法在感染后治疗长期神经精神病症状方面表现有前途.

科学领域:

神经科学是一个神经科学.
心血管医学心血管医学
传染性疾病传染性疾病

背景情况:

由于二次炎症反应,COVID-19可能导致长期认知障碍,失眠,焦虑和抑郁.
远程缺血调节 (RIC) 是一种非侵入性方法,可以调节炎症反应并保护器官.

研究的目的:

研究RIC在改善COVID-19相关的失眠患者的神经精神症状方面的疗效.
评估RIC对认知功能,睡眠质量,疲劳,焦虑和抑郁的影响.

主要方法:

一项随机,安慰剂控制,双盲试验,涉及65名COVID-19相关失眠患者.
使用MoCA,PSQI,FS-14,ESS,HAMA和HAMD-17进行神经精神症状的评估.
血清NDE,补充和线粒体蛋白质的量化.

主要成果:

在治疗后3个月,RIC显著改善了MoCA得分,并降低了PSQI,FS-14,ESS,HAMA和HAMD-17得分 (P<0.001).
对所有测量的神经精神病症状 (P < 0.003) 观察到分组时间的显著相互作用效应.
在停止RIC治疗后三个月,症状的改善持续了.

结论:

RIC显示出作为一种有效的辅助疗法的潜力,用于管理COVID-19后的神经精神病学后果.
这些发现表明,RIC可以缓解认知缺陷,睡眠障碍和与COVID-19后条件相关的情绪障碍.

关键词:

在 COVID-19 疫情中,认知障碍是一种认知障碍.这是一种炎症炎症炎症炎症.失眠是因为失眠.远程缺血预先条件远程缺血预先条件

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