当神经第一次说话时:IgG4相关的疾病被外围神经病变揭露
Yi Zhou1,2, Xinran Ma1,3,4, Jinxia Zhao5
1Department of Neurology, Peking University Third Hospital, Beijing, China.
Frontiers in neurology
|March 9, 2026
概括
周围神经病变可能是免疫球蛋白G4相关疾病 (IgG4-RD) 的初始症状. 这种状况的特点是神经损伤和器官扩大,对皮质类固醇治疗反应良好.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 免疫球蛋白G4相关性疾病 (IgG4-RD) 是一种免疫媒介的疾病,通常表现为多器官扩大和血清IgG4水平升高.
- 周围神经病变的IgG4-RD初始呈现很少见,主要记录在病例报告中.
研究的目的:
- 调查IgG4相关疾病 (IgG4-RD) 的临床特征,当外围神经病变是突出的初始表现时.
- 阐明IgG4-RD带有外围神经病变的诊断和治疗含义.
主要方法:
- 进行了对16例 (15种文献,1种机构) IgG4相关疾病与初始外围神经病变的回顾性审查.
- 分析的数据包括临床表现,器官参与,电生理学发现和治疗结果.
主要成果:
- 发病的中位数年龄为64.5岁 (13名男性,3名女性).
- 常见的初始症状包括四肢麻木和虚弱,以及器官扩大和周围神经损伤 (脱线/轴突损伤).
- 所有患者对口服皮质类固醇反应良好,在3例中使用了免疫抑制剂.
结论:
- 周围神经病变可能是IgG4相关疾病的初始表现特征.
- 与IgG4-RD相关的神经病变显示出对皮质类固醇治疗的良好反应.
- 添加免疫抑制剂应根据具体情况考虑.
关键词:
皮质类固醇治疗治疗.脱髓化多神经病变是一种多神经病变.血清IgG4升高的情况与免疫球蛋白G4相关的疾病.一个单单尿道多重性炎.涉及多个器官的参与.周围神经病变 (Peripheral Neuropathy) 是一种神经病变.更多相关视频
09:39Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
10.2K
07:30A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
10.1K
相关概念视频
Peripheral Artery Disease I: Introduction
521
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
521
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
566
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
566
Peripheral Artery Disease IV: Nursing Management
520
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
520
