慢性部和肩部疼痛患者的个体内结构共变网络:纵向大脑结构分析
Tianci Liu1, Zhiqiang Qiu1, Jia Ming2
1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Frontiers in neurology
|March 9, 2026
概括
慢性部和肩部疼痛 (CNSP) 患者表现出大脑网络的改变,特别是在右下额头环中. 最少侵入性干预导致这些网络的结构恢复,这表明个性化疼痛管理的潜力.
科学领域:
- 神经成像和神经科学 神经成像和神经科学
- 疼痛医学 医学 疼痛医学
- 结构性大脑网络 结构性大脑网络
背景情况:
- 现有的神经成像研究将慢性部和肩部疼痛 (CNSP) 与皮质形态变化联系起来.
- 人们对大脑结构网络特征和CNSP患者的个体变异性了解有限.
- 在治疗CNSP后对大脑网络变化的纵向研究很少.
研究的目的:
- 研究与健康对照组 (HCs) 相比,在CNSP患者中研究个人层面的结构共变性网络.
- 为了检查CNSP的最小侵入性干预后大脑结构网络的纵向变化.
- 为了确定潜在的神经成像生物标志物用于CNSP的治疗反应.
主要方法:
- 结构性脑部MRI和临床数据从25名CNSP患者治疗前和干预后3个月收集.
- 构建了个人层面的结构共差网络,以比较CNSP患者和HC患者.
- 经过微创手术后,评估了纵向网络变化.
主要成果:
- 与HC相比,CNSP患者在右下额头 (pars triangularis) 中表现出较低的中心度和节点效率,干预后恢复显著.
- 全球网络拓在CNSP患者中显示了小世界的特性 (玛和西格玛指数) 的下降,没有观察到显著的恢复.
- 基线水平中心度在右下额头状回路与疼痛减轻负相关,表明预后值.
结论:
- 这项研究提供了对 CNSP 中央疼痛机制的纵向洞察.
- 改变的结构性大脑网络,特别是右下额头,是CNSP的特征,可以在治疗后恢复.
- 识别的网络变化及其与疼痛减轻的相关性可以作为预测治疗反应和指导个性化治疗的生物标志物.
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