多模式MRI评估Ofatumumab在复发性多发性硬化症中对大脑结构,功能和临床相关的神经保护作用
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Jing An1,2, Xiaoshuang Wang1, Zhaoshi Zheng1
1Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Frontiers in neurology
|March 9, 2026
概括
在复发性多发性硬化症 (RMS) 患者的Ofatumumab (OFA) 治疗显示出改善的运动功能和保留的大脑结构. OFA可以通过增强白质完整性和胸膜皮层连接性来提供神经保护.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 复发性多发性硬化症 (RMS) 涉及神经炎症和神经退行,导致残疾.
- 反CD20单克隆抗体Ofatumumab (OFA) 是一种潜在的RMS疾病修饰疗法.
研究的目的:
- 为了评估Ofatumumab (OFA) 在复发性多发性硬化症 (RMS) 中的神经保护作用,使用多模式MRI.
- 评估使用OFA治疗RMS患者的大脑结构和功能变化.
主要方法:
- 一项回顾性队列研究,将16名接受OFA (治疗组) 的RMS患者与8名先前未接受治疗的患者 (无治疗组) 进行比较.
- 多模式3TMRI包括3DT1加权,扩散张力成像 (DTI) 和静止状态功能性MRI (rs-fMRI).
- 临床评估包括EDSS,T25FW和认知测试.
主要成果:
- 接受OFA治疗的组表现出改善的运动功能和减少焦虑,认知能力稳定.
- 在OFA组中观察到白质完整性 (微分异质) 和甲状腺皮层功能连接性显著增加.
- 没有治疗的组表现出灰色质缩,而OFA组显示出保留的大脑结构.
结论:
- 在复发性多发性硬化症 (RMS) 中,Ofatumumab (OFA) 治疗可以保持大脑结构和功能.
- 神经保护作用可能涉及thalamocortical网络的调制和白质完整性的恢复.
- 在RMS管理中,OFA显示出作为神经保护剂的潜力.
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