在患有散播卡波西肉瘤的人类免疫缺陷病毒患者的同时出现,HHV8和其他机会性感染:病例报告
Maggie H Zhou1, Jeffrey A Thomas2, Shari R Lipner3
1Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Case reports in oncology
|March 9, 2026
概括
这一案例突出了人类免疫缺陷病毒 (HIV) 和人类疹病毒-8 (HHV8) 同感染的患者的诊断挑战. 识别卡波西肉瘤炎症性细胞因子风暴 (KICS) 对于适当的管理至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染增加了对机会性感染的易感性.
- 卡波西肉瘤 (KS) 是由人类疹病毒-8 (HHV8) 引起的恶性瘤,可导致高HHV8和艾滋病毒病毒症患者的KS炎症性细胞因子风暴 (KICS).
- KICS是一种罕见的,严重的疾病,死亡率高,呈现出类似败血症的症状.
研究的目的:
- 为了呈现一个复杂的病例,一个患有控制不良的艾滋病毒和多种并发感染的患者.
- 突出各种感染的重叠症状所带来的诊断挑战.
- 强调区分KICS与免疫受损患者其他炎症状况的重要性.
主要方法:
- 一个患有艾滋病毒的患者和疑似KICS的病例报告.
- 诊断工作包括皮肤和淋巴结的活检.
- 实验室测试评估了多种病毒和细菌感染,炎症标志物和HIV/HHV8病毒性.
主要成果:
- 患者出现发烧,呼吸不良,腹痛,体重减轻和特征性皮肤病变.
- 同时感染的感染包括HHV8,简单疹病毒,细胞大脑病毒,MRSA,腺病毒和鼻病毒/肠病毒.
- 活检证实了和HHV8,淋巴结显示KS形态. 患者表现出全细胞减小和炎症标志物升高.
结论:
- 区分KICS与其他感染性炎症和皮肤病变的原因至关重要.
- 超母球蛋白血症是HHV8相关疾病的潜在指标.
- 及时识别KICS对于将管理转向控制炎症反应而不是仅针对感染至关重要.
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