在3HP时代,儿童家庭接触结核病预防疗法的不遵守及其预测因素:一项多中心观察性研究
Woretaw Sisay Zewdu1, Muluken Adela Alemu1, Tilaye Arega Moges2
1Department of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
在埃塞俄比亚家庭接触者中,结核病预防疗法 (TPT) 的遵守率较低,近28%的家庭不遵守. 诸如年龄,并发症和不良反应等因素显著影响TPT的成功,需要改善咨询和监督.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 药物治疗 坚持药物治疗
背景情况:
- 预防性药物治疗是预防结核病的一个关键干预措施.
- 治疗坚持不良显著限制了结核病预防治疗 (TPT) 的有效性.
研究的目的:
- 调查埃塞俄比亚西北部家庭接触者中TPT不遵守的决定因素.
- 为了评估3HP方案实施后的坚持.
主要方法:
- 一项多中心的回顾性研究在埃塞俄比亚西北部进行.
- 从494个符合TPT资格的家庭联系人 (年龄15岁) 收集数据.
- 用单变量和多变量逻辑回归模型来识别不遵守的预测因素.
主要成果:
- 在家庭接触者中观察到高水平的TPT不遵守率 (27.94%) .
- 不坚持的重要预测因素包括年龄 (5-15岁),父母身份,并发症,营养状况不佳,不良药物反应,缺乏坚持支持和TPT疗法类型.
- 特定调整的赔率比率 (AORs) 强调了与这些因素相关的风险增加.
结论:
- 埃塞俄比亚西北部家庭接触者中高水平的TPT不遵守率不足于国家目标.
- 改善TPT的坚持需要强有力的患者咨询和一致的例行监督.
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