相关实验视频

Updated: Mar 10, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

血基表观遗传生物标记在类风湿性关节炎:当前的知识和未来的前景

Agnieszka Mołoń¹, Hubert Kubis¹, Joanna Żurawska¹

¹Laboratory of Diagnostic and Clinical Epigenetics Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszów, Poland.

Frontiers in immunology

|March 9, 2026

概括

基于血液的表观遗传特征显示出早期风湿性关节炎 (RA) 检测和个性化治疗的前景. 这些标记物,包括DNA甲基化和非编码RNA (ncRNAs),可以反映疾病活动并预测治疗反应.

科学领域:

风湿病学和免疫学
表观遗传学和分子生物学
生物标志物发现发现

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节的破坏和残疾.
由于目前诊断标准的局限性,早期检测RA具有挑战性,特别是在血清阴性患者中.
诸如DNA甲基化和非编码RNA (ncRNAs) 等表观遗传机制在RA病变发生过程中发挥着作用.

研究的目的:

审查目前关于类风湿性关节炎 (RA) 血基表观遗传变化的知识.
突出表观遗传特征作为RA的诊断和预后生物标志物的潜力.
强调RA早期检测和精准医学方面的进步.

主要方法:

结构化的文献搜索使用关键词与RA相关,表观遗传学和基于血液的生物标志物.
专注于2020年至2025年间发表的研究.
合成DNA甲基化,基因组修饰和外围血液中的各种ncRNA数据.

主要成果:

基于血液的表观遗传特征与RA疾病活性相关.
新出现的数据表明,这些特征可以作为预后生物标志物,并预测治疗反应.
多层表观遗传特征为个性化治疗策略提供了潜力.

结论:

基于血液的表观遗传变化对于了解RA病变的产生非常有价值.
周围血液中的表观遗传特征对RA诊断和预后具有显著的翻译潜力.
这些生物标志物可以促进早期检测,并指导RA管理中的精准医学.

关键词:

通过DNA甲基化.通过RNA甲基化.表观遗传学是指表观遗传学.基质子的修改基质子的修改没有编码的RNAs.周围血液中的生物标志物类风湿性关节炎类风湿性关节炎

更多相关视频

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...