相关实验视频
Updated: Mar 10, 2026

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.3K
在自身免疫性疾病中的外体非编码RNA:分子机制和潜在的应用
Yunbing Wu1, Xia Li2, Yue Jin3
1Department of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China.
Frontiers in immunology
|March 9, 2026
概括
携带非编码RNA (ncRNA) 的外体是自身免疫性疾病 (AD) 的关键调节者. 准这些外体ncRNA为ADs提供了有前途的诊断和治疗潜力,尽管目前临床翻译存在挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 自身免疫性疾病 (ADS) 涉及免疫系统对自身组织的攻击,导致慢性炎症和损伤.
- 目前的AD治疗侧重于晚期炎症,往往产生低于最佳的长期结果.
- 外基因组通过转移诸如非编码RNA (ncRNA) 等分子来促进细胞间通信和免疫调节.
研究的目的:
- 审查外体ncRNAs在ADs病变发生中的调节作用.
- 突出外体ncRNAs作为诊断生物标志物和ADs的治疗点的潜力.
- 讨论基于外体ncRNA的疗法的临床转化所面临的挑战和未来方向.
主要方法:
- 关于ADs外体ncRNA研究近期进展的文献综述.
- 专注于特定的AD:系统性红斑狼 (SLE),类风湿性关节炎 (RA),1型糖尿病 (T1DM),炎症性肠病 (IBD) 和Sjögren综合征 (SS).
- 分析ncRNA类型,包括微RNA (miRNA),长非编码RNA (lncRNA) 和圆形RNA (circRNA).
主要成果:
- 外体的ncRNAs关键调节免疫反应,氧化应激,自和ADs中的细胞周期.
- 特定的外体ncRNA已被确定为各种ADs的发展和进展中的关键参与者.
- 这些ncRNA显示出作为早期诊断的敏感生物标志物和新型治疗干预的目标的潜力.
结论:
- 外体的ncRNA是自身免疫性疾病发病的关键媒介.
- 向外体ncRNAs为开发ADs的精确诊断和治疗策略提供了一个有希望的途径.
- 克服分娩,稳定性和免疫性方面的挑战对于成功的临床转化至关重要.
相关概念视频
Autoimmune Disorders
2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Overview of Exosomes
3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K
lncRNA - Long Non-coding RNAs
10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
siRNA - Small Interfering RNAs
18.9K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.9K
Experimental RNAi
8.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.1K

