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缺铁与腹腔疾病之间的隐藏联系:从临床角度看
Laura Tarancon-Diez1,2, Guillermo Perez-Cabeza3, Pilar Sanchez-Mingo4
1Pediatric Infections Group, Health Research Institute Gregorio Marañón (IiSGM), Madrid, Spain.
几乎一半的铁缺乏症患者患有乳病 (CD),包括大量患有血清阴性CD的人在标准查中错过了. 这突显了一个被诊断不足的免疫媒介肠病变.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 性疾病 (CD) 是一种由引发的免疫媒介肠病.
- 它是铁缺乏症 (ID) 的常见但未被确诊的原因.
- 在无法解释的ID中建议对CD进行查,但对绝对ID的患病率的数据有限.
研究的目的:
- 在绝对ID的个体中确定马什1 (SSCDM1) 确诊CD和疑似血清阴性CD的频率.
- 描述这些疾病的临床,血清学,组织学和免疫遗传学特征.
主要方法:
- 追溯研究86个人 (≥14年) 绝对ID (费里素<50 ng/mL).
- 所有参与者都接受了血清检测,十二指肠活检和HLA-DQ2/DQ8基因定型.
- 在血清阴性患者中,由Marsh 1组织学和允许的HLA基因型定义的SSCDM1.
主要成果:
- 14%的人确诊患有CD (Marsh 3),39.5%的人患有SSCDM1.
- 只有三分之一的确诊的CD病例是血清阳性; 77%是无症状的.
- SSCDM1患者的费里丁,肝素和IgA水平较低,类似于CD,这表明共享的吸收不良机制.
结论:
- 几乎一半的参与者有明显或血清阴性CD,表明连续性.
- 这些发现突出了未被认可的血清阴性CD和免疫介导的十二指肠损伤.
- 标准的血清学查可能会错过这些对质敏感肠病的病例.
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