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已故和活着的肝脏捐赠者的标准化评估协议:新兴肝脏移植计划的实用框架

Pablo Coste Murillo^1,2, Rodrigo Álvarez Buitrago^1,2, Vanessa López Jara¹

¹Liver Unit, Hospital R.A. Calderón Guardia, San José, Costa Rica.

Frontiers in transplantation

|March 9, 2026

概括

本综述为肝移植 (LT) 捐赠者评估提供了一个标准化的框架,改善了全球已故捐赠者 (DDLT) 和活体捐赠者 (LDLT) 计划的一致性和安全性. 它综合了全球最佳实践,以更好地利用移植和程序增长.

科学领域:

肝病学和移植外科手术
器官捐献和移植科学器官捐献和移植科学

背景情况:

肝移植 (LT) 对末期肝病至关重要,但已故供体LT (DDLT) 和活供体LT (LDLT) 的实践在全球范围内有所不同.
基础设施,政策和临床实践的差异影响了DDLT和LDLT的实施,特别是在开发计划方面.

研究的目的:

综合当前的指导方针和专家的共识,对LT的捐赠者评估.
为DDLT和LDLT捐赠者评估提供标准化,基于证据的框架.
促进与国际标准一致的可重复性协议,以提高一致性和质量保证.

主要方法:

采用了叙事审查方法.
综合了当代指南,专家共识文件和对捐赠者评估的高影响力临床研究.
开发了一个整合医疗,放射学,伦理和心理社会领域的框架.

主要成果:

最佳的DDLT需要有效的供体管理,准确的死亡确定和彻底的传染病查.
LDLT需要严格的心理社会和解剖学评估以确保捐赠者的安全.
机器输液等创新和扩展的捐赠者标准提高了结果和移植的可访问性.

结论:

本次审查提出了一种实用,协调的方法,在各种医疗保健系统中对LT捐赠者评估.
采用这种框架可以提高捐赠者的安全性,并优化移植的利用率.
该框架支持全球DDLT和LDLT计划的可持续增长.

关键词:

是已故的捐赠者.捐赠者评价捐赠者评价新兴项目计划新兴项目扩展标准捐赠者捐赠者肝移植肝移植肝移植活着的捐赠者是活着的捐赠者移植协议移植协议移植协议

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