接受和承诺疗法调节免疫炎症反应和神经变因子在老年中风患者的恒温:一个随机对照试验
Jing Wang1, Haiyan Gu2, Xiaorong Hu3
1Ningbo Rehabilitation Hospital, Center for Cognitive Psychological Rehabilitation, Ningbo, Zhejiang, 315000, China.
Journal of medical biochemistry
|March 9, 2026
概括
接受和承诺疗法 (ACT) 通过改善免疫平衡和减少炎症,帮助老年中风患者. 这种疗法还可以增强神经营养因子,减轻氧化应激,以改善恢复.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 心理治疗 心理治疗
背景情况:
- 老年脑中风 (CS) 患者面临复杂的病理生理学挑战,影响恢复.
- 了解干预措施对免疫和神经变因子的调节效应对于慢性中风管理至关重要.
研究的目的:
- 研究接受和承诺疗法 (ACT) 对老年CS患者T淋巴细胞子集,炎症性细胞因子,神经营养因子和氧化应激标志物的调节效应.
- 提供对多维病理生理相互作用和慢性中风恢复的潜在干预策略的见解.
主要方法:
- 一项随机对照试验,涉及120名老年中风患者,将ACT干预与传统治疗进行比较.
- 综合评估包括T细胞分布,血清细胞因子,神经营养因子和氧化应激标志物,使用流细胞计,HPLC-ECD和ELISA.
主要成果:
- ACT显著调节T细胞子集,抑制了促炎性细胞因子 (IL-1β,IL-6,TNF-α) 和增加了抗炎性IL-10.
- 与传统治疗相比,ACT在恢复免疫平衡和减轻炎症方面表现出更好的疗效.
- 治疗ACT导致神经变因子升高和氧化应激标志物改善,增强神经变活性和减轻氧化损伤.
结论:
- 接受和承诺疗法 (ACT) 通过多目标机制为老年中风患者提供神经保护.
- ACT调节T细胞子集恒温,调节神经营养因子,并抑制氧化应激.
- ACT提供了一个有前途的干预策略,可以改善慢性中风恢复的结果.
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