成年人髓扩散中线质瘤呈现与正静性低血压:一个病例报告
Mizuho Inoue1, Kentaro Mori1, Shinichi Numazawa1
1Department of Neurosurgery, Tokyo General Hospital, Tokyo, Japan.
NMC case report journal
|March 9, 2026
概括
骨髓中的罕见的扩散性中线质瘤 (H3K27-改变) 在成年人中引起严重的正静性低血压. 这一案例凸显了脑部成像在患有不明原因低血压和神经症状的患者的需要.
科学领域:
- 神经瘤学神经瘤学
- 神经学 神经学
- 病理学 病理学 病理学
背景情况:
- 扩散型中线结质瘤,H3K27变异,是一种罕见且具有攻击性的中枢神经系统瘤,主要影响儿童.
- 成人病例不太常见,人们对其了解甚少,特别是在非典型表现方面.
研究的目的:
- 报告第一个成年人中出现严重正静性低血压的骨髓扩散中线质瘤 (H3K27变异) 的病例.
- 强调神经成像在患有不明原因低血压和神经缺陷的患者的诊断重要性.
主要方法:
- 一个43岁的妇女的病例报告,神经症状进展.
- 诊断工作包括倾斜表测试,大脑磁共振成像 (MRI) 和用免疫组织化学进行基因病理检查.
- 治疗包括部分瘤切除,辅助化疗或放射治疗.
主要成果:
- 这名患者被诊断出背骨髓的轴内质量,确认为H3K27改变的扩散中线质瘤.
- 尽管最初的运动有所改善,但持续的严重静止性低血压严重影响了康复.
- 骨髓在巴罗反射调节中的作用强调了骨髓瘤与血压失调之间的联系.
结论:
- 骨髓扩散型中线质瘤可以在成年人中呈现出严重的正静性低血压.
- 这一案例强调了对新发病或严重正静性低血压的患者进行脑部MRI的必要性,特别是同时出现神经症状的患者.
- 及时诊断和管理对于改善患者的治疗结果至关重要.
相关概念视频
Alterations in Blood Pressure
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Assessment of blood pressure in brachial artery(one-step method)
This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
Prepare for the Procedure:
Blood Pressure Imbalances and Circulatory Shock
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...


