在GLP-1受体激动剂使用者中脱发的患病率和预测因素:来自沙特阿拉伯的横截面研究
Sali Alharbi1, Azzam Alkhalifah2
1College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Skin appendage disorders
|March 9, 2026
概括
脱发影响超过70%的葡萄糖类-1受体激动剂 (GLP-1 RA) 用户,比临床试验高出10倍. 这种副作用显著影响治疗的坚持,特别是在体重减轻的女性中.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RA) 对于体重管理是有效的.
- 新出现的数据表明GLP-1 RA使用与头发脱落增加之间存在潜在联系.
- 在沙特阿拉伯的GLP-1RA使用者中脱发的患病率和风险因素需要调查.
研究的目的:
- 为了确定沙特阿拉伯GLP-1RA用户中脱发的流行率.
- 为了确定与GLP-1RA诱导的脱发相关的风险因素.
- 评估脱发对治疗坚持和停止治疗的临床影响.
主要方法:
- 在152名现有和前GLP-1RA使用者 (不包括先前出现脱发的患者) 中进行了横截面调查.
- 经过验证的问卷调查评估了脱发的发生率,相关因素,以及对停止治疗的影响.
- 多变量逻辑回归确定了脱发的独立预测因素.
主要成果:
- 70.4%的参与者报告脱发,明显高于临床试验数据 (3-7%).
- 患病率最高的是蒂尔泽帕提德 (76.7%),其次是塞马格卢提德 (64%) 和利拉格卢提德 (54.5%).
- 独立预测因素包括更大的体重减轻 (OR 1.79) 和女性性别 (OR 3.57). 在39.7%的受影响患者中,脱发导致停止治疗.
结论:
- 脱发是GLP-1RA在现实环境中常见的,未被认可的副作用,影响了十分之七的用户.
- 这种现象显著影响了治疗的坚持,特别是在实现显著减肥的女性中.
- 积极的患者咨询和营养支持对于维持治疗持续性至关重要.
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