康普雷普斯2.0:在用于组织病理数据处理的高性能计算集群上实现大规模分布式计算
Suhas Katari Chaluva Kumar1,2, Anindya S Paul1, Haitham Abdelazim1
1Dept. of Medicine - Section of Quantitative Health, University of Florida, Gainesville, FL.
概括
通过整合高性能计算来进行全幻灯片图像 (WSI) 大规模分析,ComPRePS 2.0 增强了计算病理学. 这种人工智能驱动的工具显著提高了病研究的可扩展性和安全性.
科学领域:
- 计算病理学计算病理学
- 数字病理学数字病理学
- 医疗信息学 医疗信息学
背景情况:
- 组织学数据的数字化成全幻灯片图像 (WSI) 推动了计算病理学的进步.
- 大规模的高分辨率图像处理对于分析复杂的生物医学数据,特别是私人患者信息至关重要.
- 现有的计算病理学工具面临着大规模数据集的可扩展性和安全性的局限性.
研究的目的:
- 开发一套先进的计算病理学套件 (ComPRePS 2.0) 解决其前身的可扩展性和安全性限制.
- 利用高性能计算集群 (HPCC) 进行高效处理千兆像素WSI.
- 增强用于临床任务和研究的组织病理幻灯片的AI驱动分析.
主要方法:
- 将计算病学套件 (ComPRePS 2.0) 与佛罗里达大学的HyperGator HPCC集成在一起.
- 使用按需的CPU,GPU和内存资源.
- 实现基于Apptainer的容器化和用于分布式计算的并行文件系统访问.
主要成果:
- 与ComPRePS 1.0.0相比,ComPRePS 2.0的性能得到了15倍的提高.
- 实现了前所未有的可扩展性和增强的安全性,用于处理大维的WSIs.
- 成功处理了920个大尺寸WSI,为病研究生成了关键数据.
结论:
- 康普雷普斯2.0提供了一个可扩展和安全的平台,用于自动化组织病理幻灯片分析.
- 与HPCC集成显著提高了数字病理学工作负载的计算能力.
- 这一进步促进了大规模数据分析,有利于研究人员,病理学家和学生了解病的进展.
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