早期非类固醇抗炎药物处方和骨骨折后的非联合:一个TrinetX匹配的队列研究
Amy Phan1, Christopher M Dussik1, Danielle Wilbur1
1Department of Orthopaedic Surgery, University of Rochester, Rochester, NY.
Journal of hand surgery global online
|March 9, 2026
概括
非类固醇抗炎药物 (NSAID) 的使用增加了非手术治疗的骨骨折的非结合风险. 操作管理可以减轻这种NSAID相关的风险,强调需要仔细的患者咨询.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨骨折是常见的手腕损伤.
- 非结合是骨骨折的严重并发症,可能需要救援手术.
- 非类固醇抗炎药物 (NSAIDs) 经常被处方用于骨折后的疼痛管理.
研究的目的:
- 为了研究NSAID使用和非联合率之间的关系,在患有骨骨折的患者中.
- 为了比较非手术和手术管理的骨骨折之间的结果,关于NSAID使用和非联合.
- 评估NSAID暴露患者在非联合后的救援程序的发生率.
主要方法:
- 使用TrinetX数据库进行回顾性队列研究.
- 在诊断后一个月内,患有骨骨折的患者通过手术或非手术管理和NSAID处方进行了分层.
- 评估了骨非结合和救援程序的发生率,使用基平方测试和赔率比率进行统计分析.
主要成果:
- 在非手术治疗的患者中,NSAID处方与脚骨非结合 (OR: 1.7) 和救援程序 (OR: 1.5) 的发生率显著增加有关.
- 在手术管理的患者中,在那些有和没有术后NSAID处方的患者之间,没有观察到非联合或救援程序率的显著差异.
- 在匹配后,在非手术组分析了总共11,629名患者,在手术组分析了1,063名患者.
结论:
- 在诊断后一个月内使用NSAID增加了非手术管理的骨骨折中非联合和救援手术的风险.
- 机械固定在操作管理中可以抵消NSAIDs对骨结合的潜在不良影响.
- 临床医生应为患者提供NSAID使用的建议,特别是当计划用于骨骨折的非手术治疗时.
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