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双转移大气压等离子体喷流调节乳腺癌干细胞中的矩阵金属蛋白酶表达

Abolfazl Soulat¹, Taghi Mohsenpour¹, Leila Roshangar²

¹Department of Atomic and Molecular Physics, Faculty of Basic Sciences, University of Mazandaran, Babolsar, 47416-13534, Iran.

Biochemistry and biophysics reports

|March 9, 2026

概括

一种新型的双转移大气压等离子体喷流 (DTAPPJ) 通过减少矩阵金属蛋白酶 (MMP) 和抑制瘤入侵和活力,有效地抑制乳腺癌干细胞 (BCSCs).

科学领域:

生物医学工程生物医学工程
等离子体物理学的物理学
癌症研究癌症研究

背景情况:

乳腺癌干细胞 (BCSCs) 驱动瘤的进展和抵抗.
矩阵金属蛋白酶 (MMPs) 介导细胞外矩阵重塑,对BCSC活动至关重要.
针对BCSC和MMP是有效治疗乳腺癌的关键.

研究的目的:

引入和评估双转移大气压等离子体喷射器 (DTAPPJ) 用于向的BCSC调制.
评估DTAPPJ在抑制MMP和降低BCSC活力的有效性.
调查DTAPPJ对BCSC采取行动的潜在机制.

主要方法:

使用了DTAPPJ系统与和工作气体.
在不同时间 (120,180,240秒) 暴露于血中的BCSCs.
使用电压功率测量和光学辐射光谱分析了血特征;评估了BCSC活力,代谢活性和MMP基因表达.

主要成果:

DTAPPJ证明了稳定的等离子体传播和低能耗 (<1W).
连续放大反应氧和物种 (RONS) 的等离子体暴露.
DTAPPJ显著抑制了多个MMP基因 (MMP-1, -2, -3, -7, -9, -10, -11, -13, -14),性能优于,导致BCSC的活力和代谢活性降低.

结论:

DTAPPJ有效地降低了BCSC的活力和MMP的表达,克服了抗氧化防御.
血治疗可能通过氧化调节调节MMPs的氧化反应敏感转录因子而起作用.
DTAPPJ提供了一个有前途的,低功耗的,通过向侵袭和BCSC可行性来治疗乳腺癌的最小侵入性治疗策略.

关键词:

乳腺癌的干细胞是干细胞.双转移大气压等离子体喷气式气体.矩阵金属蛋白酶是一种金属蛋白酶.反应性氧和物种的反应性氧和物种.

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