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与炎症性细胞因子结合的Fgfr4改善了差异化甲状腺癌复发风险预测:一项回顾性队列研究

Yongjie Hu¹, Peifei Huang¹, Yingying Sha¹

¹Shanghai University of Traditional Chinese Medicine, Department of General Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200437, China.

Journal of medical biochemistry

|March 9, 2026

概括

纤维细胞生长因子受体4 (FGFR4) 和炎症性细胞因子 (ICs) 可以预测差异化甲状腺癌 (DTC) 的复发. 结合这些标志物可以改善DTC患者的术后风险分层.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
分子生物学分子生物学

背景情况:

分化甲状腺癌 (DTC) 复发是一个重大的临床挑战.
准确的术后风险分层对于管理DTC患者至关重要.

研究的目的:

评估纤维细胞生长因子受体4 (FGFR4) 和炎症细胞因子 (ICs) 在预测DTC复发中的协同作用.
开发一个综合预测模型,以提高DTC的术后风险分层.

主要方法:

血清中FGFR4,IL-6,TNF-a和CRP的水平在102名DTC患者和98名对照人群中进行测量.
使用后勤回归和ROC分析来识别风险因素并评估诊断性能.
评估了FGFR4,ICs和术后复发之间的相关性.

主要成果:

术前的FGFR4和IC水平在DTC患者和对照人群中显著升高.
结合FGFR4和ICs的组合模型显示,与单个标志物相比,诊断性能优越 (AUC=0.931).
组合模型准确地预测了DTC患者1年的复发 (AUC=0.864).

结论:

在DTC的进展和复发中,FGFR4和IC具有协同作用.
结合FGFR4和ICs的检测显著改善了术后复发风险预测.
这种综合方法为DTC管理中的临床风险分层提供了有价值的工具.

关键词:

在FGFR4中.诊断诊断诊断诊断诊断诊断有差异化的甲状腺癌.炎症因素是炎症因素.复发性复发性复发性

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