双长菌对中风后患者认知和微生物群的影响:单盲,受控试验
Shu-Ting Lin1, Te-Hsuan Tung1,2, Yen-Nung Lin1,3,4
1School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
International journal of medical sciences
|March 9, 2026
概括
这项研究发现,Bifidobacterium longum OLP-01补充剂改善了中风后患者的认知功能和改变了肠道微生物群. 12周后,身体表现和营养状况没有显著变化.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 卒中是全球死亡和残疾的主要原因之一.
- 脑卒中后的患者经常经历营养不良,认知能力下降,运动缺陷和肠道失调.
- 肠道微生物群的改变越来越被认为是中风恢复的潜在因素.
研究的目的:
- 研究Bifidobacterium longum OLP-01对中风后患者认知功能和肠道微生物群的影响.
- 评估这种益生菌对营养状况和身体表现的影响作为次要结果.
- 探索肠道微生物群变化与认知改善之间的关系.
主要方法:
- 一个为期12周的单盲,随机,安慰剂对照试验,涉及22名中风后患者.
- 参与者接受了Bifidobacterium longum OLP-01 (2 × 10^10 CFU/天) 或安慰剂.
- 通过MoCA,Trail-Making Tests和Stroop Test评估认知功能;通过MNA评估营养状况;通过TUG和6MWT评估身体表现;通过便分析评估肠道微生物群.
主要成果:
- Bifidobacterium longum OLP-01组在蒙特利尔认知评估 (MoCA) 评分和Stroop颜色命名测试准确度中显示出显著的改善.
- 在OLP-01组的参与者证明了轨道制造测试的完成时间缩短.
- 虽然MNA得分在正常范围内略有下降,但身体表现指标 (TUG,6MWT) 在各组之间没有显著差异. 肠道微生物群的组成在两组之间显示出明显的差异.
结论:
- 12周每天补充Bifidobacterium longum OLP-01有效地改善了中风后患者的认知功能.
- 益生菌干预调节了肠道微生物群的组成,表明与认知益处的潜在联系.
- 在这个队列中,Bifidobacterium longum OLP-01并没有显著改变身体表现或整体营养状况.
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