审查肠道疾病中内脏过敏的外周和中心机制
Wenhui Tang1, Jiarui Wang1, Wenlei Wang2
1Physiology and Pathophysiology Department, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
International journal of medical sciences
|March 9, 2026
概括
内脏过敏症 (VH) 涉及器官敏感度升高,导致IBS等疾病的疼痛. 这篇评论探讨了肠道细胞,大脑活动和微生物群.
科学领域:
- 胃肠道学和神经科学
- 内脏疼痛机制的内脏疼痛机制
- 肠-大脑轴研究研究
背景情况:
- 内脏过敏性 (VH) 是功能性胃肠道疾病的关键特征,如刺激性肠综合征 (IBS) 和炎症性肠病 (IBD).
- 肝炎的特征是对内部器官的正常或轻微刺激的反应过度,导致慢性疼痛和不适.
- 虽然遗传学,压力和肠道微生物群等因素有关,但VH背后的确切机制尚不清楚.
研究的目的:
- 审查了解内脏过敏 (VH) 机制的最新进展.
- 综合目前关于肠道细胞,中枢神经系统刺激性和肠道微生物群在VH中的作用的研究.
- 阐明导致内脏疼痛过敏的外围和中心过程.
主要方法:
- 文献综述,重点关注VH研究的最新发展.
- 对调查肠道细胞对 nociceptor 敏感化的影响的研究进行分析.
- 检查与内脏疼痛调节相关的大脑核刺激性的研究.
- 审查有关肠道微生物群在VH中的作用的新兴证据.
主要成果:
- 肠道细胞显著影响 nociceptors的敏感化,有助于VH.
- 处理内脏疼痛的大脑区域的兴奋度增加在过敏症中起着至关重要的作用.
- 肠道微生物群因其对VH发展的新和重大贡献而越来越受认可.
- 周围和中心机制在VH的病理生理学中相互联系.
结论:
- 冠状动脉炎涉及外围因素 (肠道细胞,微生物群) 和中央处理 (大脑活动) 之间的复杂相互作用.
- 进一步的动物和临床研究对于充分了解VH机制至关重要.
- 更好地了解VH对于开发有效的治疗方法来缓解IBS和IBD患者的痛苦至关重要.
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