相关实验视频

Updated: Mar 10, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

11.6K

双基因酶OTULIN调节神经元中的tau表达和RNA代谢

Karthikeyan Tangavelou1, Virginie Bondu1, Mingqi Li2

  • 1Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131.

Genomic psychiatry : advancing science from genes to society
|March 9, 2026
PubMed
概括

研究人员发现,双基因酶OTULIN通过调节聚,在阿尔茨海默病 (AD) 中发挥关键作用. 抑制或去除OTULIN降低了tau水平,表明它是阿尔茨海默病和相关痴呆症 (ADRD) 的潜在治疗标.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.自动炎症是一种自发性炎症.自自是一种自的过程.卢巴克 (Lubac) 的一个地方.具有Ml链接的无处不在素.奥图林 (OTULIN) 是一个古老的城市.蛋白质酶体是一种蛋白质酶体.降解RNA的降解RNA的降解RNA代谢,RNA代谢的过程RNA结合蛋白质是RNA结合的蛋白质.塔乌·塔乌 (Tau Tau) 是一个乌比奎丁是一种存在的药物.神经纤维状的纠结

更多相关视频

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.8K
Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples09:45

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples

Published on: May 10, 2015

10.2K

相关概念视频

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.5K
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
10.0K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.8K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

3.6K
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
9.1K
Regulated Protein Degradation02:58

Regulated Protein Degradation

3.3K