24小时门诊血压和C-反应蛋白:一个系统性审查和元分析
Joanna Sulicka-Grodzicka1,2, Karolina Piotrowicz3, Marcin Cwynar3
1Department of Rheumatology and Immunology, Jagiellonian University Medical College, Cracow, Poland.
Clinical hypertension
|March 9, 2026
概括
C-反应蛋白 (CRP) 可能与炎症和高血压有关,但这种关系并不总是线性的. 较高的CRP水平 (≥3 mg/L) 与成人24小时血压升高有显著的关联.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 炎症与高血压的发展有关.
- 在高血压病理生理学中C反应蛋白 (CRP) 的特定作用需要澄清.
研究的目的:
- 在成年患者中系统地审查和元分析CRP水平与24小时血压 (BP) 之间的关联.
主要方法:
- 从2013年1月到2023年6月,对主要数据库 (PubMed,Embase,Web of Science,Scopus) 的系统文献搜索.
- 包括横截面和队列研究,但不包括具有临床意义的炎症的研究.
- 计算24小时BP指数与CRP水平之间的皮尔森相关系数.
主要成果:
- 包括20项研究 (10,799名参与者) 在内.
- 在CRP水平≥3 mg/L的研究中,发现了CRP和24小时心和腹血压之间的显著正相关性 (r=0.79,SBP的P<0.001;DBP的R=0.83,P<0.001).
- 当所有研究一起分析时,没有观察到CRP和24小时BP之间的显著相关性.
结论:
- C-反应蛋白 (CRP) 可能作为炎症-高血压联系的相关生物标志物.
- CRP和高血压之间的关系在所有CRP值范围中可能不是线性的.
相关概念视频
01:21Sites for measuring blood pressure
Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
The Brachial Artery: Primary Site for Blood Pressure Measurement
01:28Special considerations while measuring blood pressure
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the patient.
01:17Measurement of Blood Pressure
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...