CD8+ T

Dongwook Lee1, Yoontae Lee1

  • 1Department of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Immune network
|March 9, 2026
PubMed
概括

由于持续的抗原暴露导致的T细胞耗尽,涉及原始耗尽的CD8+ T (Tpex) 细胞分化为细胞毒性耗尽的CD8+ T (Tex) 细胞. 了解Tex细胞异质性是改善癌症免疫疗法的关键.

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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